Central IKKβ inhibition prevents air pollution mediated peripheral inflammation and exaggeration of type II diabetes

Air Pollution and Type 2 Diabetes

According to the International Diabetes Federation in the year 2011, diabetes mellitus (DM) affects at least 366 million people worldwide, and that number is expected to reach 566 million by the year 2030. Over 99% of all diabetes cases represent type 2 DM with most of these projected to occur in lowto middle-income countries. Technology innovations, globalization with its free movement of food...

Air pollution and inflammation in type 2 diabetes: a mechanism for susceptibility.

BACKGROUND Particulate air pollution has been associated with several adverse cardiovascular health outcomes, and people with diabetes may be especially vulnerable. One potential pathway is inflammation and endothelial dysfunction-processes in which cell adhesion molecules and inflammatory markers play important roles. AIM To examine whether plasma levels of soluble intercellular adhesion mol...

Ambient air pollution and early manifestation of type 1 diabetes.

Disrupted Nitric Oxide Metabolism from Type II Diabetes and Acute Exposure to Particulate Air Pollution.

Type II diabetes is an established cause of vascular impairment. Particulate air pollution is known to exacerbate cardiovascular and respiratory conditions, particularly in susceptible populations. This study set out to determine the impact of exposure to traffic pollution, with and without particle filtration, on vascular endothelial function in Type II diabetes. Endothelial production of nitr...

Effect of environmental air pollution on type 2 diabetes mellitus.

OBJECTIVE Air pollution is a novel risk factor for insulin resistance and occurrence of type 2 diabetes mellitus (T2DM), but the evidence is limited and diverse. Therefore, the aim of this study was to assess the effect of environmental air pollution on incidence of type 2 diabetes mellitus. METHODS In this study, we identified 102 published studies through a systematic data base search inclu...